Exer 3/6 Treadmill for Mice and Rats

Exer 3/6 Treadmill for Mice and Rats

Exer-3/6 is a general purpose three (rats) or six (mice) lane animal exerciser utilizing single belt construction with dividing walls suspended over the tread surface. Exer-3/6 can be supplied with or without a stimulus assembly. An electrical stimulus system option is composed of six shock grids, each with individual on/off switches. Stimulus intensity is adjustable and LED lamps indicate which stimulus grid is active. Design of electrical stimulus grid reflects special attention to avoid injuries to animals. Animals are exercised in three or six compartments made of durable plastic (clear Lexan or opaque PVC). An included drive motor controller provides smooth and continuous adjustment of speed in the range 3-100 m/m. The exercising belt is made with special material that facilitates the animals' grip and is easy to clean.

Software included, provides remote control over the treadmill and settings for speed and acceleration, records distance traveled and data is saved in CSV format for Excel or similar statistical software.

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3 individual lanes for rats
6 individual lanes for mice
Software Included
Single belt construction
Unique wide range of speed adjustable from 3 to 100 meters per minute
Automated speed calibration mode
Adjustable Acceleration in 0.1 Meter/minute-steps per second
Programmable Acceleration profiles (requires use of software)
Digital display of Distance Traveled
Adjustable inclination: 0-25°
Electrical Stimulus with individual on/off switches per lane (manual)
Electric Stimulus Auto-off (requires shock detection option)
Belt texture facilitates animal grip

Physical Dimensions

Overall dimensions: 33" x 20" x 20" (33 x 50.8 x 50.8cm)
Each exercise lane dimensions: Rats: 17.25"L x 4.75"W x 5"H (43.8 x 12 x 12.7 cm)
Mice: 17.25"L x 2.37"W x 5"H (43.8 x 6 x 12.7 cm)
Stimulus area (shocking grid area):
Rats: 4.5" x 4.75" (11.4 x 12cm)
Mice: 4.5" x 2.37" (11.4 x 6cm)
Stimulus current: 0 to 1.5mA (adjustable)
Stimulus voltage: 163V
Repetition Rate: 1Hz, 2Hz, or 3Hz (adjustable)
Tread inclination: 0 to 25° in 5° steps
Optional Tread Decline: -15 to 0° in 5° steps

Data Collected

On the digital display

  • Distance (global odometer)
  • Speed

In Software program

  • Distance (global odometer)
  • Speed

Shock Detection option adds these parameters:

  • Number shock grid visits per lane (NOV)
  • Number of total shock impulses per subject (NOS)
  • Individual subject Distance Traveled
  • Time spent running (TOB)

Complete Systems

Exer 3/6 Treadmill

1050RMExer-3/6 Treadmill without Shock for Rats(3) & Mice(6)
1055SRMExer-3/6 Treadmill with Shock for Rats(3) & Mice(6)
1055SDRMExer-3/6 Treadmill with Shock and Shock Detection for Rats(3) & Mice(6)
1050DHExer-3/6 Treadmill Exer-3/6 Open Treadmill Downhill Running Adapter

Optional & Replacement Items

Consult with our service department for repair or replacement items.

Contact us for current pricing

Please include your name, institution, and location.
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The Journal of Physiology Volume 584 Issue 3 Page 997-1009, November 2007
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Ethan J. Anderson, Hanae Yamazaki, and P. Darrell Neufer
J. Biol. Chem., Vol. 282, Issue 43, 31257-31266, October 26, 2007
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Ethan J. Anderson, Hanae Yamazaki and P. Darrell Neufer
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Chen, Yu-Wen ; Chen, Sheng-Hsien ; Chou, Willy ; Lo, Yi-Ming ; Hung, Ching-Hsia ; Lin, Mao-Tsun
British Journal of Sports Medicine. 41(9):597-602, September 2007.
Low intensity training decreases markers of oxidative stress in skeletal muscle of mdx mice
Jan J. Kaczor, Julie E. Hall, Eric Payne and Mark A. Tarnopolsky
Free Radical Biology and Medicine Volume 43, Issue 1, 1 July 2007, Pages 145-154
Muscarinic cholinoceptors in the ventromedial hypothalamic nucleus facilitate tail heat loss during physical exercise
Samuel P. Wanner, Juliana B. Guimarães, Luiz Oswaldo C. Rodrigues, Umeko Marubayashi, Cândido C. Coimbra and Nilo R.V. Lima
Brain Research Bulletin Volume 73, Issues 1-3, 15 June 2007, Pages 28-33
Role of tumour necrosis factor alpha, but not of cyclo-oxygenase-2-derived eicosanoids, on functional and morphological indices of dystrophic progression in mdx mice: a pharmacological approach
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Giselle M. Petzinger, John P. Walsh, Garnik Akopian, Elizabeth Hogg, Avery Abernathy, Pablo Arevalo, Patty Turnquist, Marta Vukovi, Beth E. Fisher, Daniel M. Togasaki, and Michael W. Jakowec
The Journal of Neuroscience, May 16, 2007, 27(20):5291-5300; doi:10.1523/JNEUROSCI.1069-07.2007
Effects of different types of physical exercise on the staining of parvalbumin-positive neurons in the hippocampal formation of rats with epilepsy
Ricardo Mario Arida, Carla Alessandra Scorza, Fulvio Alexandre Scorza, Sergio Gomes da Silva, Maria da Graça Naffah-Mazzacoratti and Esper Abrão Cavalheiro
Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 31, Issue 4, 9 May 2007, Pages 814-822
Physical training in developing rats does not influence the kindling development in the adult life
Ricardo Mario Arida, Fulvio Alexandre Scorza, Aline Fabiana Silva de Lacerda, Sergio Gomes da Silva and Esper Abrão Cavalheiro
Physiology & Behavior Volume 90, Issue 4, 16 March 2007, Pages 629-633
Response of caspase-independent apoptotic factors to high salt diet-induced heart failure
Parco M. Siu, Soochan Bae, Natalya Bodyak, Debra L. Rigor and Peter M. Kang
Journal of Molecular and Cellular Cardiology Volume 42, Issue 3, March 2007, Pages 678-686
Activation of the central cholinergic pathway increases post-exercise tail heat loss in rats
Thales N. Prímola-Gomes, Washington Pires, Luiz O.C. Rodrigues, Cândido C. Coimbra, Umeko Marubayashi and Nilo R.V. Lima
Neuroscience Letters Volume 413, Issue 1, 8 February 2007, Pages 1-5
VDAC1 serves as a mitochondrial binding site for hexokinase in oxidative muscles
Keltoum Anflous-Pharayra, Zong-Jin Cai and William J. Craigen
Biochimica et Biophysica Acta (BBA) - Bioenergetics Volume 1767, Issue 2, February 2007, Pages 136-142
The effects of forced exercise on hippocampal plasticity in the rat: A comparison of LTP, spatial- and non-spatial learning
Rachel M. O’Callaghan, Robert Ohle and Áine M. Kelly
Behavioural Brain Research Volume 176, Issue 2, 25 January 2007, Pages 362-366
A Foxo/Notch pathway controls myogenic differentiation and fiber type specification
Tadahiro Kitamura, Yukari Ido Kitamura, Yasuhiro Funahashi, Carrie J. Shawber, Diego H. Castrillon, Ramya Kollipara, Ronald A. DePinho, Jan Kitajewski and Domenico Accili
J. Clin. Invest. 117(9): 2477-2485 (2007).
Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans
Daniel G MacArthur, Jane T Seto, Joanna M Raftery, Kate G Quinlan, Gavin A Huttley, Jeff W Hook, Frances A Lemckert, Anthony J Kee, Michael R Edwards, Yemima Berman, Edna C Hardeman, Peter W Gunning, Simon Easteal, Nan Yang & Kathryn N North
Nature Genetics 39, 1261 - 1265 (2007)
Oxidative Stress Induced by Intense and Exhaustive Exercise Impairs Murine Cognitive Function
Eloi F. Rosa, Shirley Takahashi, Jeannine Aboulafia, Viviane L. A. Nouailhetas and Maria G. M. Oliveira
J Neurophysiol 98: 1820-1826, 2007
Endurance training restores peritoneal macrophage function in post-MI congestive heart failure rats
M. L. Batista, Jr., R. V. T. Santos, E. M. Oliveira, M. C. L. Seelaender, and L. F. B. P. Costa Rosa
J Appl Physiol 102: 2033-2039, 2007
Does K-11706 Enhance Performance and Why?
S. Imagawa, K. Matsumoto, M. Horie, N. Ohkoshi, T. Nagasawa, T. Doi, N. Suzuki, M. Yamamoto
Physiology & Biochemistry Int J Sports Med 2007; 28: 928-933
Exercise performance and muscle contractile properties after creatine monohydrate supplementation in aerobic-anaerobic training rats
Nickolay Boyadjiev , Dobrin Popov and Slavi Delchev
Journal of Sports Science and Medicine (2007) 6, 423-428
Exercise-induced HSP-72 elevation and cardioprotection against infarct and apoptosis.
John C. Quindry, Karen L. Hamilton, Joel P. French, Youngil Lee, Zsolt Murlasits, Nihal Tuner, and Scott K. Powers
J Appl Physiol 103: 1056-1062, 2007
The transcriptional co-activator PGC-1b drives the formation of oxidative type IIX fibers in skeletal muscle.
Arany Z, NK LeBrasseur, C Morris, II Rybkin, E Smith, W Yang, Y Ma, B Lowell, BM Spiegelman
Cell Metab, 5:35-46, 2007.
Increased submaximal insulin-stimulated glucose uptake in mouse skeletal muscle after treadmill exercise
Taku Hamada, Edward B. Arias, and Gregory D. Cartee
J Appl Physiol, Nov 2006; 101: 1368 - 1376.
Differential effect of troponin T mutations on the inotropic responsiveness of mouse hearts - role of myofilament Ca2+ sensitivity increase
Syevda G. Sirenko, James D. Potter and Björn C. Knollmann
The Journal of Physiology, Volume 575 Issue 1 Page 201 - August 2006
Deficits in acetylcholine homeostasis, receptors and behaviors in choline transporter heterozygous mice
M. H. Bazalakova, J. Wright, E. J. Schneble, M. P. McDonald, C. J. Heilman, A. I. Levey R. D. Blakely
Genes, Brain and Behavior, Received 24 April 2006, revised 19 July 2006, accepted for publication 21 July 2006
Mild forced treadmill exercise enhances spatial learning in the aged rat
David S. Albeck, Kazuhiro Sano, Gayle E. Prewitt and Lori Dalton
Behavioural Brain Research Volume 168, Issue 2, 3 April 2006, Pages 345-348
Body-wide gene therapy of Duchenne muscular dystrophy in the mdx mouse model
Michela Alessandra Denti, Alessandro Rosa, Giuseppe D’Antona, Olga Sthandier, Fernanda Gabriella De Angelis, Carmine Nicoletti, Mariacarmela Allocca, Orietta Pansarasa, Valeria Parente, Antonio Musarò, Alberto Auricchio, Roberto Bottinelli, and Irene Bozzoni
PNAS | March 7, 2006 | vol. 103 | no. 10 | 3758-3763
Increased Muscle Mass With Myostatin Deficiency Improves Gains in Bone Strength With Exercise
Mark W Hamrick, Ted Samaddar, Catherine Pennington, John McCormick
Journal of Bone and Mineral Research, March 2006
In vivo detection of exercise-induced ultrastructural changes in genetically-altered murine skeletal muscle using polarization-sensitive optical coherence tomography
James J. Pasquesi, Simon C. Schlachter, Marni D. Boppart, Eric Chaney, Stephen J. Kaufman, Stephen A. Boppart
20 February 2006 / Vol. 14, No. 4 / OPTICS EXPRESS 1549
Exercise Training Attenuates Acute Doxorubicin-Induced Cardiac Dysfunction.
Chicco, Adam J PhD; Schneider, Carole M PhD; Hayward, Reid PhD
Journal of Cardiovascular Pharmacology. 47(2):182-189, February 2006
Facioscapulohumeral muscular dystrophy in mice overexpressing FRG1
Davide Gabellini, Giuseppe D'Antona, Maurizio Moggio, Alessandro Prelle, Chiara Zecca, Raffaella Adami, Barbara Angeletti, Patrizia Ciscato, Maria Antonietta Pellegrino, Roberto Bottinelli, Michael R. Green and Rossella Tupler
Nature 439, 973-977 (23 February 2006)
Evidence that brain nitric oxide inhibition increases metabolic cost of exercise, reducing running performance in rats
Ana Cristina R. Lacerda, Umeko Marubayashi, Cláudio H. Balthazar and Cândido C. Coimbra
Neuroscience Letters Volume 393, Issues 2-3, 30 January 2006, Pages 260-263
Enhanced Mitochondrial Sensitivity to Creatine in Rats Bred for High Aerobic Capacity
B. Walsh, R. B. Hooks, J. E. Hornyak, L. G. Koch, S. L. Britton, and M. C. Hogan
J Appl Physiol (January 19, 2006)
α7ß1 Integrin Regulates Mechanotransduction and Prevents Skeletal Muscle Injury
Marni D Boppart, Dean J Burkin, and Stephen J Kaufman
Am J Physiol Cell Physiol (January 18, 2006)
Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia
Björn C. Knollmann, Nagesh Chopra, Thinn Hlaing, Brandy Akin, Tao Yang, Kristen Ettensohn, Barbara E.C. Knollmann, Kenneth D. Horton, Neil J. Weissman, Izabela Holinstat, Wei Zhang, Dan M. Roden, Larry R. Jones, Clara Franzini-Armstrong and Karl Pfeifer
J. Clin. Invest. 116:2510-2520 (2006)
Transforming growth factor-{beta} in the brain regulates fat metabolism during endurance exercise
Toma Ishikawa, Wataru Mizunoya, Tetsuro Shibakusa, Kazuo Inoue, and Tohru Fushiki
Am J Physiol Endocrinol Metab 291: E1151-E1159, 2006
Effect of Aerobic Physical Exercise in Pinealectomized Animals Submitted to the Pilocarpine Model of Epilepsy
Marcelo Reina Siliano, Eliângela Lima, Sandra Gomes Valente, Maria da Graça Naffah-Mazzacoratti, Esper Abrão Cavalheiro, Ricardo Mario Arida,, Débora Amado
J Epilepsy Clin Neurophysiol 2006; 12(2):63-68
Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice
Gregory J. Pelka, Catherine M. Watson, Tania Radziewic, Melinda Hayward, Hooshang Lahooti, John Christodoulou and Patrick P. L. Tam
Brain 2006 129(4):887-898
Low-intensity exercise training during doxorubicin treatment protects against cardiotoxicity
Adam J. Chicco, David S. Hydock, Carole M. Schneider, and Reid Hayward
J Appl Physiol 100: 519-527, 2006.
F110I and R278C Troponin T Mutations That Cause Familial Hypertrophic Cardiomyopathy Affect Muscle Contraction in Transgenic Mice and Reconstituted Human Cardiac Fibers*
Olga M. Hernandez, Danuta Szczesna-Cordary, Björn C. Knollmann, Todd Miller, Michael Bell Jiaju Zhao, Syevda G. Sirenko, Zoraida Diaz, Georgianna Guzman, Yuanyuan Xu, Ying Wang, W. Glenn L. Kerrick, and James D. Potter
J. Biol. Chem., Vol. 280, Issue 44, 37183-37194, November 4, 2005
Transplantation of Neuronal and Glial Restricted Precursors into Contused Spinal Cord Improves Bladder and Motor Functions, Decreases Thermal Hypersensitivity, and Modifies Intraspinal Circuitry
Takahiko Mitsui, Jed S. Shumsky, Angelo C. Lepore, Marion Murry, and Itzhak Fischer
The Journal of Neuroscience, October 19, 2005 25(42):9624-9636
The Interaction of a New Motor Skill and an Old One: H-Reflex Conditioning and Locomotion in Rats
Yi Chen, Xiang Chen, , Lyn B. Jakeman, Gerwin Schalk, Bradford T. Strokes, and Jonathan R. Wolpaw
The Journal of Neuroscience, July 20, 2005 - 25(29):6898-6906
Antioxidants and ecto-5'-nucleotidase are not involved in the training-induced cardioprotection against ischaemia-reperfusion injury
María Morán, Isabel Blázquez, Ana Saborido and Alicia Megías
Experimental Physiology Volume 90 Page 507 - July 2005
Long-term exercise training and angiotensin-converting enzyme inhibition differentially enhance myocardial capillarization in the spontaneously hypertensive rat.
Ziada, Amal M a; Hassan, Mohammed O a; Tahlilkar, Khurram I a; Inuwa, Ibrahim M b
Journal of Hypertension. 23(6):1233-1240, June 2005.
Exercise might favor reverse cholesterol transport and lipoprotein clearance: Potential mechanism for its anti-atherosclerotic effects
Chen Wei, Meera Penumetcha, Nalini Santanam, Ya-Guang Liu, Mahdi Garelnabi and Sampath Parthasarathy
Biochimica et Biophysica Acta (BBA) - General Subjects Volume 1723, Issues 1-3, 25 May 2005, Pages 124-127
Exercise Capacity of Mice Genetically Lacking Muscle Glycogen Synthase IN MICE, MUSCLE GLYCOGEN IS NOT ESSENTIAL FOR EXERCISE*
Bartholomew A. Pederson§, Carlie R. Cope, Jill M. Schroeder, Micah W. Smith, José M. Irimia¶, Beth L. Thurberg||, Anna A. DePaoli-Roach, and Peter J. Roach
J. Biol. Chem., Vol. 280, Issue 17, 17260-17265, April 29, 2005
Response of XIAP, ARC, and FLIP apoptotic suppressors to 8 wk of treadmill running in rat heart and skeletal muscle
Parco M. Siu, Randall W. Bryner, Zsolt Murlasits, and Stephen E. Alway
J Appl Physiol 99: 204-209, 2005. First published March 17, 2005
Muscle regeneration in the prolonged absence of myostatin
Kathryn R. Wagner , Xiaosong Liu §, Xiaoli Chang, ¶, and Ronald E. Allen §
PNAS | February 15, 2005 | vol. 102 | no. 7 | 2519-2524
Poster abstracts from the 35th Meeting of the International Sun Valley Workshop on Skeletal Tissue Biology July 31-August 3, 2005, Sun Valley, Idaho, USA
M. Hamrick, C. Pennington, H. Chen, C. Isales, P. McNeil
J Musculoskelet Neuronal Interact 2005; 5(4):369-378
Transcriptional basis for exercise limitation in male eNOS-knockout mice with age: heart failure and the fetal phenotype
Caroline Ojaimi, Wei Li, Shintaro Kinugawa, Heiner Post, Anna Csiszar, Pal Pacher, Gabor Kaley, and Thomas H. Hintze
Am J Physiol Heart Circ Physiol 289: H1399-H1407, 2005
Biphasic temporal pattern in exercise capacity after myocardial infarction in the rat: relationship to left ventricular remodeling
Nathan A. Trueblood, Patrick R. Inscore, Daniel Brenner, Daniel Lugassy, Carl S. Apstein, Douglas B. Sawyer, and Wilson S. Colucci
Am J Physiol Heart Circ Physiol 288: H244-H249, 2005
Strain-dependent differences in responses to exercise training in inbred and hybrid mice
Michael P. Massett and Bradford C. Berk
Am J Physiol Regul Integr Comp Physiol 288: R1006-R1013, 2005
Mice lacking COX10 in skeletal muscle recapitulate the phenotype of progressive mitochondrial myopathies associated with cytochrome c oxidase deficiency
Francisca Diaz, Christine K. Thomas, Sofia Garcia, Dayami Hernandez and Carlos T. Moraes
Human Molecular Genetics 2005 14(18):2737-2748
Differential serial sarcomere number adaptations in knee extensor muscles of rats is contraction type dependent
Timothy A. Butterfield, Timothy R. Leonard, and Walter Herzog
J Appl Physiol 99: 1352-1358, 2005
Roles of Exercise and Pharmacokinetics in Cerivastatin-Induced Skeletal Muscle Toxicity
Jennifer L. Seachrist,, Cho-Ming Loi, Mark G. Evans, Kay A. Criswell and Charles E. Rothwell
Toxicological Sciences 2005 88(2):551-561
Treadmill Training Effects in Different Age Groups following Middle Cerebral Artery Occlusion in Rats
Ray-Yau Wang, Shang-Ming Yu, Yea-Ru Yang
Gerontology 2005;51:161-165
A Multidisciplinary Evaluation of the Effectiveness of Cyclosporine A in Dystrophic Mdx Mice
Annamaria De Luca, Beatrice Nico, Antonella Liantonio, Maria Paola Didonna, Bodvael Fraysse, Sabata Pierno, Rosa Burdi, Domenica Mangieri, Jean-François Rolland, Claudia Camerino, Alberta Zallone, Paolo Confalonieri, Francesca Andreetta, Elisa Arnoldi, Isabelle Courdier-Fruh, Josef P. Magyar, Antonio Frigeri, Michela Pisoni, Maria Svelto and Diana Conte Camerino
American Journal of Pathology. 2005;166:477-489
Physical training reverts hippocampal electrophysiological changes in rats submitted to the pilocarpine model of epilepsy
Ricardo Mario Arida, Emilio Rafael Garrido Sanabria, Andre Cesar da Silva, Leonardo Coutinho Faria, Fulvio Alexandre Scorza and Esper Abrão Cavalheiro
Physiology & Behavior Volume 83, Issue 1, 30 October 2004, Pages 165-171
Regulation of Muscle Fiber Type and Running Endurance by PPARδ
PLoS Biology | October 2004 | Volume 2 | Issue 10 | e294
Yong-Xu Wang, Chun-Li Zhang, Ruth T. Yu, Helen K. Cho, Michael C. Nelson, Corinne R. Bayuga-Ocampo, Jungyeob Ham, Heonjoong Kang, Ronald M. Evans
Differential effects of spontaneous versus forced exercise in rats on the staining of parvalbumin-positive neurons in the hippocampal formation
Ricardo Mario Arida, Carla Alessandra Scorza, Alexandre Valotta da Silva, Fulvio Alexandre Scorza and Esper Abrão Cavalheiro
Neuroscience Letters Volume 364, Issue 3, 8 July 2004, Pages 135-138
Aerobic Exercise Attenuates Airway Inflammatory Responses in a Mouse Model of Atopic Asthma
A. Pastva, K. Estell, T. R. Schoeb, T. P. Atkinson, and L. M. Schwiebert
J. Immunol., April 1, 2004; 172(7): 4520 - 4526
Alterations in Apoptosis Regulatory Factors During Hypertrophy and Heart Failure
Peter M. Kang, Patrick Yue, Zhilin Liu, Oleg Tarnavski, Natalya Bodyak, and Seigo Izumo
Am J Physiol Heart Circ Physiol (March 4, 2004).
Alterations in Apoptosis Regulatory Factors During Hypertrophy and Heart Failure
Peter M. Kang, Patrick Yue, Zhilin Liu, Oleg Tarnavski, Natalya Bodyak, and Seigo Izumo
Am J Physiol Heart Circ Physiol (March 4, 2004).
Platelet-derived growth factor improves cardiac function in a rodent myocardial infarction model.
Zheng, Jingang; Shin, Jin H.; Xaymardan, Munira; Chin, Andrew; Duignan, Inga; Hong, Mun K.; Edelberg, Jay M.
Coronary Artery Disease. 15(1):59-64, February 2004.
Responses of rat myocardial antioxidant defences and heat shock protein HSP72 induced by 12 and 24-week treadmill training
M. Morán, J. Delgado, B. González, R. Manso and A. Megías
Acta Physiologica Scandinavica Volume 180 Issue 2 Page 157 - February 2004
Genetic determinants on rat chromosome 6 modulate variation in the hypercapnic ventilatory response using consomic strains.
M.R. Dwinell, H.V. Forster, J. Petersen A. Rider M.P. Kunert, A.W. Cowley, Jr., H.J. Jacob.
J Appl Physiol (January 20, 2005). doi:10.1152/japplphysiol.01148.2004
Exercise Training Reduces Neointimal Growth and Stabilizes Vascular Lesions Developing After Injury in Apolipoprotein E-Deficient Mice
Marianne Pynn, MD; Katrin Schäfer, MD; Stavros Konstantinides, MD; Martin Halle, MD
Circulation. 2004;109:386-392
Effects of AT1 Receptor Block Begun Late in Life on Normal Cardiac Aging in Rats
Saupe, Kurt W. PhD ; Sobol, Sophie C. MA ; Koh, Stanley G. MA ; Apstein, Carl S. MD
Journal of Cardiovascular Pharmacology. 42(4):573-580, October 2003.
The α1A/C- and α1B-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse
Timothy D. O'Connell,1 Shinji Ishizaka,2 Akihiro Nakamura,3 Philip M. Swigart,1 M.C. Rodrigo,1 Gregory L. Simpson, Susanna Cotecchia, D. Gregg Rokosh, William Grossman, Elyse Foster, and Paul C. Simpson
J Clin Invest. 2003 June 1; 111 (11): 1783-1791
Slowing of rat diaphragm action potential depolarization by endurance treadmill training
Erik van Lunteren and Michelle Moyer
Neuroscience Letters Volume 339, Issue 3, 27 March 2003, Pages 175-178
Early and late treadmill training after focal brain ischemia in rats
Yea-Ru Yang, Ray-Yau Wang and Paulus Shyi-Gang Wang
Neuroscience Letters Volume 339, Issue 2, 20 March 2003, Pages 91-94
Pleiotropy, Homeostasis, and Functional Networks Based on Assays of Cardiovascular Traits in Genetically Randomized Populations
Joseph H. Nadeau, Lindsay C. Burrage, Joe Restivo, Yoh-Han Pao, Gary Churchill and Brian D. Hoit
Genome Research 13:2082-2091, 2003
Differential transcriptional activation of select metabolic genes in response to variations in exercise intensity and duration
Audrey L. Hildebrandt, Henriette Pilegaard, and P. Darrell Neufer
Am J Physiol Endocrinol Metab 285: E1021-E1027, 2003. First published August 5, 2003
Enhanced Dystrophic Progression in mdx Mice by Exercise and Beneficial Effects of Taurine and Insulin-Like Growth Factor-1
Annamaria De Luca, Sabata Pierno, Antonella Liantonio, Michela Cetrone, Claudia Camerino, Bodvael Fraysse, Massimo Mirabella, Serenella Servidei, Urs T. Rüegg and Diana Conte Camerino
Pharmacology and Experimental Therapeutics; Vol. 304, Issue 1, 453-463, January 2003
Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat muscles
Niels Jessen, Rasmus Pold, Esben S. Buhl, Lasse S. Jensen, Ole Schmitz, and Sten Lund
J Appl Physiol 94: 1373-1379, 2003. First published December 20, 2002
Role of c-Src in regulation of endothelial nitric oxide synthase expression during exercise training
Michael E. Davis, Hua Cai, Louise McCann, Tohru Fukai, and David G. Harrison
Am J Physiol Heart Circ Physiol 284: H1449-H1453, 2003. First published December 5, 2002
Characterization of Cardiac Conduction System Abnormalities in Mice with Targeted Disruption of Six5 Gene
Hiroko Wakimoto, Colin T. Maguire, Megan C. Sherwood, Marcel M. Vargas, Partha S. Sarkar, Jennifer Han, Sita Reddy and Charles I. Berul
Journal of Interventional Cardiac Electrophysiology, Volume 7, Number 2, October 2002, 127 - 135
Paroxysmal Dyskinesias in the Lethargic Mouse Mutant
Zubair Khan and H. A. Jinnah
The Journal of Neuroscience, September 15, 2002, 22(18):8193-8200
Activation of the ERK Pathway and Atypical Protein Kinase C Isoforms in Exercise- and Aminoimidazole-4-carboxamide- 1-beta -D-riboside (AICAR)-stimulated Glucose Transport*
Hubert C. Chen, Gautam Bandyopadhyay, Mini P. Sajan, Yoshinori Kanoh, Mary Standaert, Robert V. Farese Jr., and Robert V. Farese
J. Biol. Chem., Vol. 277, Issue 26, 23554-23562, June 28, 2002
Abnormal collagen fibrils in tendons of biglycan/ fibromodulin-deficient mice lead to gait impairment, ectopic ossification, and osteoarthritis
Vol. 16 May 2002 The FASEB Journal 673-680
Naturally Occurring Variation in Cardiovascular Traits among Inbred Mouse Strains
Brian D. Hoit, Songsak Kiatchoosakun, Joseph Restivo, Darryl Kirkpatrick, Keith Olszens, Haifeng Shao, Yoh-Han Pao and Joseph H. Nadeau
Genomics Volume 79, Issue 5, May 2002, Pages 679-685
Donley, D A. ; Bryner, R W. Riggs, D R. ; Jackson, B ; White, J S. Siu, P M. ; Langley, J G. ; Alway, S E. FACSM
Medicine & Science in Sports & Exercise. 34(5) Supplement 1:S78, May 2002
Modular flexibility of dystrophin: Implications for gene therapy of Duchenne muscular dystrophy
Citrate synthase expression and enzyme activity after endurance training in cardiac and skeletal muscles
Parco M. Siu, David A. Donley, Randall W. Bryner, and Stephen E. Alway
J Appl Physiol 94: 555-560, 2003; doi:10.1152/japplphysiol.00821.2002
Protective effects of treadmill training on infarction in rats
Ray-Yau Wang, Yea-Ru Yang and Shang-Ming Yu
Brain Research Volume 922, Issue 1, 13 December 2001, Pages 140-143
Location and distribution of Fos protein expression in rat hippocampus following acute moderate aerobic exercise
Akinniran Oladehin and Robert S. Waters
Experimental Brain Research, Issue: Volume 137, Number 1, March 2001, 26 - 35
Munc18c Regulates Insulin-stimulated GLUT4 Translocation to the Transverse Tubules in Skeletal Muscle
Ahmir H. Khan, Debbie C. ThurmondDagger, Chunmei Yang, Brian P. Ceresa§, Curt D. Sigmund, and Jeffrey E. Pessin
J. Biol. Chem., Vol. 276, Issue 6, 4063-4069, February 9, 2001
Exercise Intolerance in Rats With Hypertensive Heart Disease Is Associated With Impaired Diastolic Relaxation
Marco Guazzi; Daniel A. Brenner; Carl S. Apstein; Kurt W. Saupe
Hypertension. 2001;37:204
Chronic Exercise Alters Caudal Hypothalamic Regulation of the Cardiovascular System in Hypertensive Rats
Jeffrey M. Kramer, Joseph A. Beatty, Hugh R. Little, Edward D. Plowey, and Tony G. Waldrop
The American Physiological Society, 280: (2001) pp. R389-R397
Cell Therapy Attenuates Deleterious Ventricular Remodeling and Improves Cardiac Performance After Myocardial Infarction
Mohit Jain; Harout DerSimonian, PhD; Daniel A. Brenner, MA; Soeun Ngoy; Paige Teller, MA; Albert S. B. Edge, PhD; Agatha Zawadzka; Kristie Wetze; Douglas B. Sawyer, MD, PhD; Wilson S. Colucci, MD; Carl S. Apstein, MD; Ronglih Liao, PhD
Circulation. 2001;103:1920
Bioassayable growth hormone release in rats in response to a single bout of treadmill exercise
A. J. Bigbee, K. L. Gosselink, R. R. Roy, R. E. Grindeland, and V. R. Edgerton
J Appl Physiol, Dec 2000; 89: 2174 - 2178.
Effects of exercise training on cardiac function, gene expression, and apoptosis in rats
Hongkui Jin, Renhui Yang, Wei Li1, Hsienwie Lu, Anne M. Ryan, Annie K. Ogasawara, John Van Peborgh, and Nicholas F. Paoni
Am J Physiol Heart Circ Physiol Vol. 279, Issue 6, H2994-H3002, December 2000
Exercise in the heat is limited by a critical internal temperature
T. J. Walters, K. L. Ryan, L. M. Tate, and P. A. Mason
J Appl Physiol, Aug 2000; 89: 799 - 806.
Effects of exercise training on LV performance and mortality in a murine model of dilated cardiomyopathy
Kirk T. Spencer, Keith Collins, Claudia Korcarz, Richard Fentzke, Roberto M. Lang, and Jeffrey M. Leiden
Am J Physiol Heart Circ Physiol 279: H210-H215, 2000
Deleterious effects of chronic clenbuterol treatment on endurance and sprint exercise performance in rats
Noel D. DUNCAN, David A. WILLIAMS and Gordon S. LYNCH
Clinical Science (2000) 98, 339-347
Does 3-adrenoreceptor blockade attenuate acute exercise-induced reductions in leptin mRNA?
S. Brooke Bramlett, Jun Zhou, Ruth B. S. Harris, Stephen L. Hendry, Trudy L. Witt, and Jeffrey J. Zachwieja
J Appl Physiol, Nov 1999; 87: 1678 - 1683.
Chronic and acute exercise do not alter Ca2+ regulatory systems and ectonucleotidase activities in rat heart
Jerónimo Delgado, Ana Saborido, María Morán, and Alicia Megías
J Appl Physiol, Jul 1999; 87: 152 - 160.
Phenotypic differences in cardiovascular regulation in inbred rat models of aerobic capacity
Physiological Genomics 1:63-69 (1999)
Initiation of Locomotion in Mammals
Annals of the New York Academy of Sciences Volume 860 Page 83 - November 1998
Exercise training enhances adrenergic constriction and dilation in the rat spinotrapezius muscle
Julia M. Lash
J Appl Physiol Vol. 85, Issue 1, 168-174, July 1998
HSP70 expression in the CNS in response to exercise and heat stress in rats
T. J. Walters, K. L. Ryan, M. R. Tehrany, M. B. Jones, L. A. Paulus, and P. A. Mason
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ACE Inhibition Reduces Left Ventricular Mass Independent of Pressure Without Affecting Coronary Flow and Flow Reserve in Spontaneously Hypertensive Rats
The American Journal of the Medical Sciences:Volume 314(1)July 1997pp 21-27
Time- and order-dependent changes in functional and NO-mediated dilation during exercise training
Julia M. Lash and H. Glenn Bohlen
Journal of Applied Physiology Vol. 82, No. 2, pp. 460-468, February 1997
Enalapril and Losartan Reduced Cardiac Mass and Improved Coronary Hemodynamics in SHR
Eduardo Nunez; Kazuyoshi Hosoya; Dinko Susic; Edward D. Frohlich
Hypertension. 1997;29:519
Interaction between clenbuterol and run training: effects on exercise performance and MLC isoform content
C. P. Ingalls, W. S. Barnes, and S. B. Smith
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Spontaneous motor activity and physical endurance of young and old mice
Pagala M.; Ravindran K.; Namba T.; Grob D.
Electroencephalography and Clinical Neurophysiology/ Electromyography and Motor Control, Volume 97, Number 4, September 1995, pp. 92-92(1)
Gordon S. Lynch, Noel D. Duncan, Siun P. Campbell and David A. Williams
Clinical and Experimental Pharmacology and Physiology Volume 22 Issue 6-7 Page 430-437, July 1995
Contribution of arterial feed vessels to skeletal muscle functional hyperemia
J. M. Lash
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Myostatin Inhibition Enhances the Effects of Exercise on Performance and Metabolic Outcomes in Aged Mice
Nathan K. LeBrasseur, Teresa M. Schelhorn, Barbara L. Bernardo, Patricia G. Cosgrove, Paula M. Loria and Thomas A. Brown
The Journals of Gerontology: Series A Volume 64A, Issue 9 Pp. 940-948
Physical exercise during the adolescent period of life increases hippocampal parvalbumin expression
Sérgio Gomes da Silva, Flávia Doná, Maria José da Silva Fernandes, Fulvio Alexandre Scorza, Esper Abrão Cavalheiro and Ricardo Mario Arida
Brain and Development doi:10.1016/j.braindev.2008.12.012
SNO-hemoglobin is not essential for red blood cell|[ndash]|dependent hypoxic vasodilation
T Scott Isbell , Chiao-Wang Sun , Li-Chen Wu , Xinjun Teng , Dario A Vitturi , Billy G Branch , Christopher G Kevil , Ning Peng , J Michael Wyss , Namasivayam Ambalavanan , Lisa Schwiebert , Jinxiang Ren , Kevin M Pawlik , Matthew B Renfrow , Rakesh P Patel & Tim M Townes
Nature Medicine 14, 773-777 (1 July 2008)
Activation of the PPAR/PGC-1{alpha} Pathway Prevents a Bioenergetic Deficit and Effectively Improves a Mitochondrial Myopathy Phenotype
T. Wenz, F. Diaz, B. Spiegelman, C. Moraes
Cell Metabolism, Volume 8, Issue 3, Pages 249-256
Haihong Zong, Claire C. Bastie, Jun Xu, Reinhard Fassler, Kevin P. Campbell, Irwin J. Kurland and Jeffrey E. Pessin
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Oestrogen receptors mediate oestrogen-induced increases in post-exercise rat skeletal muscle satellite cells
D. L. Enns, S. Iqbal and P. M. Tiidus
Acta Physiologica Volume 194 Issue 1, Pages 81 - 93
Aging-Associated Reductions in AMP-Activated Protein Kinase Activity and Mitochondrial Biogenesis.
R. Reznick, H. Zong, J. Li, K. Morino, I. Moore, H. Yu, Z. Liu, J. Dong, K. Mustard, S. Hawley
Cell Metabolism , Volume 5 , Issue 2 , Pages 151 - 156
Exercise-induced changes in the cortical bone of growing mice are bone- and gender-specific.
J. Wallace, R. Rajachar, M. Allen, S. Bloomfield, P. Robey, M. Young, D. Kohn
Bone , Volume 40 , Issue 4 , Pages 1120 - 1127
Effect of l-Carnitine Supplementation on Endurance Exercise in Normobaric/Normoxic and Hypobaric/Hypoxic Conditions
Usha Panjwani, PhD, Lalan Thakur, BSc, Jag Parvesh Anand, BSc, Som Nath Singh, PhD, Amitabh, MSc, Shashi Bala Singh, PhD, and Pratul Kumar Banerjee, PhD
Wilderness and Environmental Medicine Article: pp. 169-176
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Shock. 23(5):426-433, May 2005
Adeel Safdar, Jonathan P. Little, Andrew J. Stokl, Bart P. Hettinga, Mahmood Akhtar, and Mark A. Tarnopolsky
J Biol Chem. 2011 Jan 18. [Epub ahead of print]
Exercise Reverses Metabolic Syndrome in High Fat Diet-Induced Obese Rats
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Med Sci Sports Exerc. 2010 Jul 7. [Epub ahead of print]
Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration
Youngmok C. Jang, Michael S. Lustgarten, Yuhong Liu, Florian L. Muller, Arunabh Bhattacharya, Hanyu Liang, Adam B. Salmon, Susan V. Brooks, Lisa Larkin, Christopher R. Hayworth, Arlan Richardson and Holly Van Remmen
The FASEB Journal vol. 24 no. 5 1376-1390
Exercise-induced alterations in extracellular signal-regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle
David L. Williamson, Neil Kubica, Scot R. Kimball and Leonard S. Jefferson
J Physiol 573 (2): 497
Disruption of Dynein/Dynactin Inhibits Axonal Transport in Motor Neurons Causing Late-Onset Progressive Degeneration.
B. LaMonte, K. Wallace, B. Holloway, S. Shelly, J. Ascaño, M. Tokito, T. Van Winkle, D. Howland, E. Holzbaur
Neuron, Volume 34, Issue 5, Pages 715-727
Exercise training restores abnormal myocardial glucose utilization and cardiac function in diabetes
Tom L. Broderick , Paul Poirier , Melissa Gillis
Diabetes/Metabolism Research and Reviews Volume 21, Issue 1 , Pages 44 - 50
Protecting the myocardium: A role for the [beta]2 adrenergic receptor in the heart.
Patterson, Andrew J. MD, PhD; Zhu, Weizhong MD, PhD; Chow, Amy; Agrawal, Rani MS; Kosek, Jon MD; Xiao, Rui Ping MD, PhD; Kobilka, Brian MD
Critical Care Medicine. 32(4):1041-1048, April 2004.
Effect of an isotonic rehydration sports drink and exercise on urolithiasis in rats
N.P. Abreu, C.T. Bergamaschi, G.S. di Marco, C.V. Razvickas, and N. Schor
Braz J Med Biol Res. [online]. Apr. 2005, vol.38, no.4 [cited 17 May 2006], p.577-582
Platelet-Derived Growth Factor-AB Promotes the Generation of Adult Bone Marrow-Derived Cardiac Myocytes
Munira Xaymardan, Lilong Tang, Leze Zagreda, Benedetta Pallante, Jingang Zheng, Joseph L. Chazen, Andrew Chin, Inga Duignan, Patrick Nahirney, Shahin Rafii, Takashi Mikawa, and Jay M. Edelberg
Circ. Res. 94: e39 -45e
Treadmill running exercise results in the presence of numerous myofibroblasts in mouse patellar tendons
Michal Szczodry, Jianying Zhang, Chanteak Lim, Hongxia L. Davitt, Torin Yeager, Freddie H. Fu, James H.-C. Wang
Journal of Orthopaedic Research Volume 27 Issue 10, Pages 1373 - 1378
Evaluation of Skeletal and Cardiac Muscle Function after Chronic Administration of Thymosin {beta}-4 in the Dystrophin Deficient Mouse
Christopher F. Spurney, Hee-Jae Cha, Arpana Sali, Gouri S. Pandey, Emidio Pistilli, Alfredo D. Guerron, Heather Gordish-Dressman, Eric P. Hoffman, Kanneboyina Nagaraju
PLoS ONE 5(1): e8976
Postnatal PPAR{delta} Activation and Myostatin Inhibition Exert Distinct yet Complimentary Effects on the Metabolic Profile of Obese Insulin-Resistant Mice
Barbara L. Bernardo, Timothy S. Wachtmann, Patricia G. Cosgrove, Max Kuhn, Alan C. Opsahl, Kyle M. Judkins, Thomas B. Freeman, John R. Hadcock, Nathan K. LeBrasseur
PLoS ONE 5(6): e11307
Functional and Molecular Effects of Arginine Butyrate and Prednisone on Muscle and Heart in the mdx Mouse Model of Duchenne Muscular Dystrophy
Alfredo D. Guerron, Rashmi Rawat, Arpana Sali, Christopher F. Spurney, Emidio Pistilli, Hee-Jae Cha, Gouri S. Pandey, Ramkishore Gernapudi, Dwight Francia, Viken Farajian, Diana M. Escolar, Laura Bossi, Magali Becker, Patricia Zerr, Sabine de la Porte, Heather Gordish-Dressman, Terence Partridge, Eric P. Hoffman, Kanneboyina Nagaraju
PLoS ONE 5(6): e11220
Stem Cell Therapy with Overexpressed VEGF and PDGF Genes Improves Cardiac Function in a Rat Infarct Model
Hiranmoy Das, Jon C. George, Matthew Joseph, Manjusri Das, Nasreen Abdulhameed, Anna Blitz, Mahmood Khan, Ramasamy Sakthivel, Hai-Quan Mao, Brian D. Hoit, Periannan Kuppusamy, Vincent J. Pompili
PLoS ONE 4(10): e7325
Ectopic Catalase Expression in Mitochondria by Adeno-Associated Virus Enhances Exercise Performance in Mice
Dejia Li, Yi Lai, Yongping Yue, Peter S. Rabinovitch, Chady Hakim, Dongsheng Duan
PLoS ONE 4(8): e6673
miRNA in the Regulation of Skeletal Muscle Adaptation to Acute Endurance Exercise in C57Bl/6J Male Mice
Adeel Safdar, Arkan Abadi, Mahmood Akhtar, Bart P. Hettinga, Mark A. Tarnopolsky
PLoS ONE 4(5): e5610
Electric Pulse Stimulation of Cultured Murine Muscle Cells Reproduces Gene Expression Changes of Trained Mouse Muscle
Nathalie Burch, Anne-Sophie Arnold, Flurin Item, Serge Summermatter, Gesa Brochmann Santana Santos, Martine Christe, Urs Boutellier, Marco Toigo, Christoph Handschin
PLoS ONE 5(6): e10970
Distinct Roles for Laminin Globular Domains in Laminin ?1 Chain Mediated Rescue of Murine Laminin ?2 Chain Deficiency
Kinga I. Gawlik, Mikael Ã…kerlund, Virginie Carmignac, Harri Elamaa, Madeleine Durbeej
PLoS ONE 5(7): e11549
Cytoplasmic CUG RNA Foci Are Insufficient to Elicit Key DM1 Features
Warunee Dansithong, Cordula M. Wolf, Partha Sarkar, Sharan Paul, Andy Chiang, Ian Holt, Glenn E. Morris, Dorothy Branco, Megan C. Sherwood, Lucio Comai, Charles I. Berul, Sita Reddy
PLoS ONE 3(12): e3968